At DolCas Biotech LLC in Landing, New Jersey, we use proven methods to get the highest quality, pure turmeric extracts from the root of the plant for use in supplements. Our BCM–95 is 100% pure turmeric extract standardized to curcumin, demethoxy curcumin, bisdemethoxy curcumin, and the essential oils of the turmeric rhizomes. The essential oils in our turmeric extract are extracted with double steam distillation, and contents of essential oils are 7–9% ar-turmerone, alpha-tumerone and beta–tumerone around 50%. Some of the other essential oils that are present in BCM–95 include:
Safety of BCM-95
The curcuminoids (curcumin, demethoxy curcumin, and bisdemethoxy curcumin) and volatile oil present in the turmeric rhizomes are responsible for a wide range of biological activities. The principle active component of turmeric, curcumin, can modulate several different transcription factors, cytokines, growth factors, kinases and other enzymes associated with various diseases. The major limitation with curcumin is its poor bioavailability. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. This led to use of high doses of turmeric extract to counter poor oral bioavailability, but at the same time raising concerns of its toxicity.
Arjuna Natural Extracts Ltd. developed a procedure enhancing the bioavailability of curcumin by combining curcuminoids and essential oils of turmeric with Ar–turmerone. The new formulation showed blood concentrations of free, unconjugated curcumin in micromolar concentrations about seven to nine times more bioavailable compared to regular curcumin. It is retained in significant amount in the blood up to 8 hours after oral dose, which are required if any clinical benefit is to accrue from ingested curcumin, based on the results of preclinical studies.
This product has been trade-named as BCM–95 (Biocurcumin). Since the higher bioavailability of curcumin from BCM–95 delivers significant levels of curcumin in vivo, we evaluated the detailed safety profile of BCM-95 aspects in various animal models.